Vijayawada | Guntur | Rajahmundry | Ongole | Visakhapatnam

TenecteRel 40 mg Injection Kit (Tenecteplase)

TenecteRel 40 mg Injection Kit contains Tenecteplase, a recombinant tissue plasminogen activator (tPA) used as a thrombolytic agent. It’s indicated for the treatment of acute ST-elevation myocardial infarction (STEMI) to reduce mortality. Administered as a single intravenous bolus, TenecteRel facilitates the dissolution of blood clots, restoring blood flow to the heart muscle.

Category

Enquiry for the Product

Product Information

TenecteRel 40 mg Injection Kit comprises Tenecteplase, a genetically engineered variant of alteplase with enhanced fibrin specificity and a prolonged half-life. These modifications allow for single-bolus administration, simplifying the thrombolytic therapy process. By binding to fibrin in the thrombus, Tenecteplase converts plasminogen to plasmin, leading to the breakdown of fibrin and dissolution of the clot. This mechanism is crucial in the management of acute myocardial infarction, aiming to promptly restore perfusion and minimize cardiac tissue damage.

Indications

TenecteRel 40 mg Injection Kit is indicated for:

  • Acute ST-Elevation Myocardial Infarction (STEMI): To reduce mortality in patients experiencing an acute STEMI.

Composition

Each kit contains:

  • Active Ingredient: 40 mg of Tenecteplase (lyophilized powder).
  • Solvent: Sterile water for injection.
  • Accessories: One sterile disposable syringe, two needles, and three alcohol swabs.

Dosage and Administration

  • Dosage: Administer as a single intravenous bolus over 5 seconds. The dose is weight-based:
    • <60 kg: 30 mg
    • 60–69.9 kg: 35 mg
    • 70–79.9 kg: 40 mg
    • 80–89.9 kg: 45 mg
    • ≥90 kg: 50 mg
  • Administration:
    • Reconstitute the lyophilized powder with the provided sterile water for injection.
    • Ensure complete dissolution before administration.
    • Administer the reconstituted solution as a single IV bolus over 5 seconds.

Note: It’s imperative to adhere to the weight-based dosing to optimize therapeutic outcomes and minimize adverse effects.

Precautions

  • Bleeding Risk: Tenecteplase can increase the risk of bleeding. Monitor patients for signs of bleeding, especially at puncture sites and in areas prone to hemorrhage.
  • Hypersensitivity: Contraindicated in patients with known hypersensitivity to Tenecteplase or any component of the formulation.
  • Recent Surgery or Trauma: Use with caution in patients who have undergone major surgery or experienced significant trauma within the past two weeks.
  • Concurrent Anticoagulant Therapy: Exercise caution when used alongside anticoagulants or antiplatelet agents due to an elevated risk of bleeding.
  • Pregnancy and Lactation: Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution is advised when administered to nursing mothers.

Storage

  • Store at 2°C to 8°C (36°F to 46°F).
  • Protect from light; keep the vial in the original carton until use.
  • Do not freeze.

Note

  • Monitoring: Regularly monitor vital signs, ECG, and clinical status during and after administration.
  • Reconstitution: Follow aseptic techniques during reconstitution and administration to prevent contamination.
  • Patient Education: Inform patients about the importance of reporting any signs of bleeding or allergic reactions promptly.

 

Enquiry for the Product

Open chat
Hello 👋
Can we help you?